Explain the mechanism of NAFLD and NASH (mention second hit

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Learning Topic 1: Inherited  Metabolic Disorder

 Question: Is tetrahydrobiopterin (BH4) useful in managing patient with Phenylketonuria?/ PKU?

(Use references in havard style and own words, explain what PKU condition is, talk about phenylalanine hydroxylase deficiency and BH4 in PKU. Remember not all patients are responsive to BH4 treatment.)

Summarise the paper below and explain why you chose the article/paper and also whether you consider the data in those paper represents a small or a significant advance in your opinion. Look at the example document provided.

References :

https://academic.oup.com/jcem/article/81/2/470/2649344
 
 
https://www.sciencedirect.com/science/article/pii/S1096719219303634?via%3Dihub
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7911353/
 
 
 Learning Topic 2 : Liver in Health and Disease

Key Question: Explain the mechanism of NAFLD and NASH (mention second hit theory/oxygen species/inflammatory cytokines). Is NASH more life threatening than NAFLD based on its association with Cirrhosis?  Use references and use your own words. Do not copy references or words from the example.

Paper References

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339475/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4943559/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098369/

Learning topic 3: Lipids and Lipoprotein Metabolism
 
 
Question:  Is omega-3 fatty acids (eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)) or statins an effective treatment in reducing cholesterol level and preventing cardiovascular disease? Give your reasons with references. Please use references and write in your own words.
 
 References:

https://onlinelibrary.wiley.com/doi/10.1111/joim.13016
https://onlinelibrary.wiley.com/doi/full/10.1111/j.0954-6820.1985.tb08887.x
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389556/

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