INSTRUCTIONS TO STUDENTS: This End-of-Route Review paper includes FIVE (5) pages (including the quilt page). You is susceptible to be to encompass the next particulars in your submission: Route Code, Title of the ECA, SUSS PI No., Your Title, and Submission Date. Leisurely submission will be subjected to the marks deduction scheme. Please check with the Pupil Handbook for facts. IMPORTANT NOTE ECA Submission Slice-off date: 03 November 2025, 12 noon ECA Submission Pointers Please practice the submission instructions acknowledged below: This ECA carries 70% of the route marks and is a compulsory ingredient. It is some distance to be executed personally and now not collaboratively with other college students. You should to put up it on time. Submission You is susceptible to be to put up the ECA project in only the identical manner as your tutormarked assignments (TMA), i.e. using Canvas. Submission in another manner savor hardcopy or another capacity might well perchance well now not be accepted. Digital transmission is now not instantaneous. It is some distance feasible that the network web explain visitors will be notably heavy on the lower-off date and connections to the map can now not be assured. Hence, you is susceptible to be suggested to put up your project the day before the cutoff date in converse to be particular that the submission is accepted and in true time. While you can accept as true with submitted your ECA project, the plight is displayed on the pc display cloak cloak. You would per chance perchance perchance handiest earn a a success project submission message whenever you happen to had applied for the electronic mail notification option. ECA Marks Deduction Plan Please be aware the next: Submission Slice-off Time – Unless otherwise suggested, the lower-off time for ECA submission will be at 12:00 noon on the day of the time restrict. All submission timings will be in accordance to the time recorded by Canvas. Begin Time for Deduction – College students are given a grace length of 12 hours. Hence calculation of leisurely submissions of ECAs will birth up at 00:00 hrs the next day (this is applicable even though it is a vacation or weekend) after the time restrict. How the Plan Works – From 00:00 hrs the next day after the time restrict, 10 marks will be deducted for each and every 24-hour block. Submissions which will likely be field to extra than 50 marks deduction will be assigned zero be aware. For examples on how the scheme works, please check with Part 5.2 Para 1.7.3 of the Pupil Handbook. Any extra info, missing appendices or corrections got after the lower-off date will furthermore now not be belief about within the grading of your ECA project. Plagiarism and Collusion Plagiarism and collusion are sorts of dishonest and are now not acceptable in any secure of a student’s work, including this ECA project. That you might steer determined of plagiarism by giving acceptable references whenever you tell some people’s ideas, phrases or photos (including diagrams). Consult with the entire info on Harvard referencing and quotation: http://www.open.ac.uk/libraryservices/paperwork/Harvard_citation_hlp.pdf That you might steer determined of collusion by ensuring that your submission is in accordance to your possess particular person effort. The digital submission of your ECA project will be screened thru a plagiarism detecting application. For added info about plagiarism and dishonest, you might perchance perchance accept as true with to mild check with the Pupil Handbook. SUSS takes a flowery stance against plagiarism and collusion. Serious instances will most frequently outcome within the student being referred to SUSS Pupil Disciplinary Neighborhood. For other instances, essential marking penalties or expulsion from the route will be imposed. Accountable Spend of Generative AI tools Whereas Generative AI tools equivalent to ChatGPT can generate responses for you, it can perchance perchance presumably now not realize the explicit context of your project. This might well perchance perchance well outcome in inappropriate solutions or errors that might well perchance presumably just affect negatively in your grades. Ought to you might want to tell these tools, it’s your responsibility to check and validate the generated explain and rephrase in your possess phrases. Do now not forget that ideas and info taken from other sources, including those derived from the tell of Generative AI tools equivalent to ChatGPT, can accept as true with to mild be wisely attributed. Fee that Turnitin can detect each and every AI generated explain and plagiarism, and you is susceptible to be field to the penalties outlined above. For added info on the responsible tell of generative AI tools and how to precisely cite them as a supply, check with SUSS Teaching and Finding out Centre’s Tutorial Integrity route (https://upward thrust.bid.com/portion/GlQuywqm9MmZkxbaGig0HjjFA73k7aBr#/) Demand 1a Compare DNA microarray evaluation and quantitative RT-PCR as ways for measuring gene expression. In your respond, record how each and every diagram works, the type of information they map, and name ONE (1) major limitation of each and every diagram. (8 marks) Demand 1b You is susceptible to be investigating how the expression of a particular gene adjustments in accordance to a drug remedy. Propose an experimental scheme to quantify this commerce in gene expression, and converse why this diagram is suitable. (7 marks) Demand 2a Compare Sanger sequencing with a subsequent-abilities sequencing (NGS) diagram (equivalent to Illumina or Nanopore). In your respond, converse the underlying principles of each and every diagram, and evaluate their throughput and usual read lengths. (8 marks) Demand 2b Focus on TWO (2) major obstacles or challenges in analyzing high-throughput sequencing info. Counsel a likely solution or scheme to manage with ONE (1) of the challenges. (7 marks) Demand 3a Compare the underlying principles of ideas of SDS-PAGE and dimension exclusion chromatography (SEC) for protein separation. Illustrate how each and every diagram separates proteins and converse the type of information each and every scheme offers. (7 marks) Demand 3b Originate a purification workflow to isolate a target protein from a posh mixture using an AKTA computerized chromatography map. In your respond, present an explanation for the main steps you might perchance perchance rob to purify a target protein, including now not now not up to ONE (1) chromatographic scheme. Uncover how you might perchance perchance verify the purity of the final protein product. (8 marks) Demand 4a Compare X-ray crystallography and nuclear magnetic resonance (NMR) spectroscopy as ways for figuring out protein structure. Listing the precept of each and every diagram and ONE (1) key encourage and ONE (1) key limitation of each and every. (8 marks) Demand 4b A novel protein has been found and not using a experimentally solved structure. Fabricate a scheme to foretell the three-d structure of this protein using computational tools, and look at how legitimate the predicted model is. (7 marks) Demand 5a Compare the working principles of Ground Plasmon Resonance (SPR) and Bio-Layer Interferometry (BLI) for studying biomolecular interactions. Appraise ONE (1) encourage of each and every diagram. (6 marks) Demand 5b Originate an experiment to score out the binding kinetics and affinity between a protein and its ligand using SPR or BLI. Your respond can accept as true with to mild present an explanation for how the experiment would be build up and how the binding info would be interpreted. (8 marks) Demand 5c Computational ideas can complement experimental interaction studies. Uncover why a computational diagram (equivalent to molecular docking) is ethical for predicting a protein–ligand interaction, and appraise ONE (1) limitation of this diagram. (6 marks) Demand 6a Review the contribution of the Human Genome Mission (HGP) to the advance of personalized medication. Toughen your respond with ONE (1) explicit example of how genomic info is old to tailor medical remedy to an particular person. (10 marks) Demand 6b Propose how genomic sequencing and evaluation is susceptible to be utilized to tune and build up an rising viral outbreak. In your respond, discuss how viral genomic info might well perchance well converse public health decisions and appraise ONE (1) misfortune linked to this diagram. (10 marks) —– END OF ECA PAPER —–
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