BME355 Genomic Sequence Analysis Slay-of-Course Review – July Semester 2025, Singapore

INSTRUCTIONS TO STUDENTS: This Slay-of-Course Review paper contains SIX (6) pages (along with the duvet page). You are to consist of the next particulars on your submission: Course Code, Title of the ECA, SUSS PI No., Your Title, and Submission Date. Dreary submission will probably be subjected to the marks deduction scheme. Please discuss with the Student Instruction manual for critical aspects. IMPORTANT NOTE ECA Submission Closing date: 10 November 2025, 12 noon ECA Submission Pointers Please notice the submission instructions said under: This ECA carries 70% of the route marks and is a compulsory factor. It is to be performed for my fragment and no longer collaboratively with other college students. You wish to put up it on time. Submission   You are to put up the ECA task in barely the an identical manner as your tutor-marked assignments (TMA), i.e. the utilize of Canvas. Submission in every other manner like hardcopy or every other manner may per chance no longer be well-liked. Electronic transmission is now not any longer instantaneous. It is that you may possibly imagine that the network traffic may possibly be specifically heavy on the closing date and connections to the machine can not be guaranteed. Hence, you are instructed to put up your task the day sooner than the cutoff date in give away to be sure the submission is well-liked and in accurate time. If you’ve submitted your ECA task, the dwelling is displayed on the pc display mask mask. You will easiest accumulate a worthwhile task submission message while you happen to had utilized for the e-mail notification option. ECA Marks Deduction Scheme Please existing the next: Submission Cleave-off Time – Until in every other case instructed, the gash-off time for ECA submission will probably be at 12:00 noon on the day of the closing date. All submission timings will probably be constant with the time recorded by Canvas. Delivery up Time for Deduction – College students are given a grace interval of 12 hours. Hence calculation of leisurely submissions of ECAs will delivery up at 00:00 hrs the next day (this applies even whether it is some distance a vacation or weekend) after the closing date. How the Scheme Works – From 00:00 hrs the next day after the closing date, 10 marks will probably be deducted for every 24-hour block . Submissions that are self-discipline to bigger than 50 marks deduction will probably be assigned zero ticket . For examples on how the scheme works, please discuss with Fragment 5.2 Para 1.7.3 of the Student Instruction manual. Any additional recordsdata, lacking appendices or corrections obtained after the closing date will furthermore no longer be regarded as in the grading of your ECA task. Plagiarism and Collusion Plagiarism and collusion are forms of dishonest and are no longer acceptable in any form of a student’s work, along with this ECA task. You may per chance steer clear of plagiarism by giving acceptable references while you utilize one other other folks’s strategies, phrases or photos (along with diagrams). Test with the full facts on Harvard referencing and quotation: http://www.launch.ac.uk/libraryservices/paperwork/Harvard_citation_hlp.pdf You may per chance steer clear of collusion by making sure that your submission is constant along with your bear in mind particular particular person effort. The electronic submission of your ECA task will probably be screened thru a plagiarism detecting tool. For additional facts about plagiarism and dishonest, you are going to bear in mind to discuss with the Student Instruction manual. SUSS takes a complicated stance in opposition to plagiarism and collusion. Critical cases will in overall lead to the student being referred to SUSS Student Disciplinary Neighborhood. For other cases, important marking penalties or expulsion from the route will probably be imposed. Responsible Exercise of Generative AI instruments   Whereas Generative AI instruments equivalent to ChatGPT can generate responses for you, it can well not understand the explicit context of your task. This may per chance per chance lead on to inappropriate answers or errors which will affect negatively to your grades. If or no longer it is some distance critical to make utilize of these instruments, it is your responsibility to look at and validate the generated philosophize and rephrase on your bear in mind phrases. Take into account that strategies and facts taken from other sources, along with these derived from the utilize of Generative AI instruments equivalent to ChatGPT, will bear in mind to be as it’d be attributed. Tell that Turnitin can detect every AI generated philosophize and plagiarism, and you may possibly possibly possibly be self-discipline to the penalties outlined above. For additional facts on the responsible utilize of generative AI instruments and the blueprint in which that you can accurately cite them as a source, discuss with SUSS Teaching and Studying Centre’s Tutorial Integrity route. https://rise.reveal.com/portion/GlQuywqm9MmZkxbaGig0HjjFA73k7aBr#/ Write My Project Rent a Professional Essay & Project Author for winding up your Tutorial Assessments Native Singapore Writers Crew 100% Plagiarism-Free Essay Very best Satisfaction Rate Free Revision On-Time Transport Inquire 1 You were assigned the duty of figuring out the functional significance of the human MAOA gene. Predicament up your findings in a logical layout as you review the gene and resolution the next questions. Encompass detailed screenshots as an instance your job. Inquire 1a What’s the elephantine name and ID of the gene? Encompass detailed screenshots to beef up your resolution. (5 marks) Inquire 1b Utilizing acceptable bioinformatics instruments, existing the actual situation of the human MAOA gene on the chromosome. Illustrate by which human tissue does the gene presentations one of the best expression. Encompass detailed screenshots to beef up your resolution. (5 marks) Inquire 1c Bid about the aim of this gene. Encompass detailed screenshots supporting  your resolution. (5 marks) Inquire 1d Listing any FIVE (5) pathways this gene is inquisitive about the utilize of Reactome pathway database because the source. Encompass the detailed screenshots to beef up your resolution. (5 marks) Inquire 2 Present your figuring out in molecular genetics by seriously evaluating the next statements. Inquire 2a Protein alignments are every so customarily most smartly-most long-established to DNA alignments. (5 marks) Inquire 2b When comparing carefully related proteins, it is counseled to make utilize of excessive worth blosum matrices (BLOSUM90) and low worth PAM matrices (PAM30). (5 marks) Inquire 2c Situation-Explicit Iterated BLAST (PSI-BLAST) is for all time extra sensitive than a fashioned BLAST search in discovering distantly related protein sequences. (5 marks) Inquire 2d The E-worth is derived from Karlin-Altschul statistics. The bigger the E-values, the extra statistically important is the BLAST consequence. (5 marks) Inquire 2e Benchmarking is a truly critical blueprint for comparing hundreds of tool instruments and evaluating their accuracy. (5 marks) Inquire 3 Search the given sequence the utilize of bioinformatics instruments and resolution the next questions: melyetspyf yqeprfydge nylpvhlqgf eppgyertel tlspeapgpl edkglgtpehcpgqclpwac kvckrksvsv drrraatlre krrlkkvnea fealkrstll npnqrlpkveilrsaiqyie rlqallssln qeerdlryrg gggpqpgvps ecsshsascs pewgsalefsanpgdhllta dptdahnlhs ltsivdsitv edvsvafpde tmpn Inquire 3a Clear up the identity of the sequence and the organism it belongs to. Utilizing screenshots, discuss the steps frail to search out out its identity. (10 marks) Inquire 3b Resolve the aim of the sequence and the conserved domains most unusual in it. Encompass detailed screenshots to beef up your resolution. (5 marks) Inquire 3c Listing TWO (2) WikiPathways by which the corresponding gene is concerned. (5 marks) Inquire 4 Utilizing the sequence talked about in Inquire 3, accumulate its homologs (one every) from other organisms equivalent to Pan troglodytes , Canis lupus dingo , Dasypus novemcinctus , Mus musculus and Rattus ratttus . Inquire 4a Paste the sequences in FASTA layout. (5 marks) Inquire 4b Assemble a a few sequence alignment the utilize of any acceptable a few sequence alignment instrument, and consist of every the alignment and the corresponding phylogenetic tree on your resolution. (10 marks) Inquire 4c Catch in thoughts the quality of the a few sequence alignment and the accuracy of the phylogenetic tree derived from it. Provide justification to your review. (5 marks) Inquire 5 Utilizing   the       OMIM             database          facts     for       Gastric             Cancer (https://omim.org/entry/613659), solve the next tasks: Inquire 5a Pull out the genes related to gastric cancer and utilize the list as input in the online instrument DAVID (Database for Annotation, Visualization and Integrated Discovery). Encompass the detailed screenshots on your resolution. (5 marks) Inquire 5b Ruin a functional annotation clustering of the gene list and consist of screenshots of the results from GOTERM_BP/CC/MF_DIRECT and KEGG_PATHWAY. (5 marks) Inquire 5c Appraise the results bought and discuss how related the findings are to the gene list. (5 marks) —– END OF ECA PAPER —– Purchase Custom Acknowledge of This Review & Enhance Your Grades Get A Free Quote

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